Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. It is important for you to practice good mouth care during treatment with Prolia. What should I know about Prolia vs. Boniva? WebYou should take calcium and vitamin D as your doctor tells you to while you receive You may report side effects to FDA at 1-800-FDA-1088. Tingling or numbness in the hands, feet, and face can develop as a symptom of severe hypocalcemia. If you have bothersome or severe side effects or other problems while taking Prolia and need to stop the medication, your doctor will monitor your bone mineral density. Prolia (denosumab) injection, for subcutaneous use. Its recommended that you take 400 international units of vitamin D and 1,000 milligrams (mg) of calcium with Prolia. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. If you have a low calcium level, you should not take Prolia. Theyre commonly used to treat osteoporosis. Musculoskeletal pain from Prolia is mild or manageable for most people. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). Continue reading, Prolia (denosumab) does increase bone density. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. Below, we answer some common questions about taking Prolia. WebNow that Im taking Prolia, do I still need calcium and vitamin D? Also, its important to brush and floss your teeth regularly while youre using Prolia. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. Bone pain from Prolia may be most noticeable in your arms and legs. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. In rare cases, your doctor may have you self-inject Prolia at home. You are encouraged to report negative side effects of prescription drugs to the FDA. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Prolia may be used off-label for RA, if you have a high risk for bone fractures. Use of the term female in this article refers to sex assigned at birth. The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. Your risk for infection with Prolia may be higher if you have a weakened immune system. Can you drink alcohol while taking Prolia? Your doctor can discuss with you how to manage side effects and whether youll need to stop taking Prolia due to side effects. All rights reserved. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. If you have any questions about Prolias side effects, talk with your doctor. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. In fact, bone breakdown is higher in the first several months after you stop Prolia. The fractures may require surgeries, take several months to heal, or both. Prolia is also available in a biosimilar form. How long will the side effects of Prolia last? Prolia may cause several side effects. Prolia injection is a brand of denosumab, which treats osteoporosis. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. WebDrug interactions are reported among people who take Prolia and Calcium. This is because its not known if Prolia is safe to receive while breastfeeding. Prolia is usually given once every 6 months. Also tell them if you smoke, drink alcohol, or use illegal drugs. Talk with your doctor about the best options for treating your condition. They may want to check for other causes. To learn more about this, see the How is Prolia administered? section below. Theyll need to confirm that you arent pregnant. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Talk with your doctor about which other treatments are better choices for you. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. These problems may include: Your risk for mouth-related side effects may be higher if you have problems with your teeth. And you should continue using birth control for at least 5 months after stopping Prolia. The drug may increase the risk of pregnancy loss. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. Its thought that hair loss could occur due to how Prolia affects your immune system. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. They have some similar uses and side effects, but they also have some differences. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. These can include tingling or numbness in the hands, feet, and face. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. It could harm the unborn baby or cause birth defects. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. MNT is the registered trade mark of Healthline Media. Call your doctor for medical advice about side effects. Low blood calcium level. Its important to tell your doctor if you have serious or ongoing side effects. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) If youd like to learn more about Prolia, talk with your doctor or pharmacist. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Studies of Prolia didnt report weight gain as a side effect of the drug. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Doing so will help you avoid the risk for a low calcium level during treatment. Theyll do this with certain tests, such as a bone scan or ultrasound. Continue reading, Prolia (denosumab) has not been associated with weight gain in clinical studies. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Before you have any dental work done, tell your dentist you are receiving this medicine. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Learn about the highest quality calcium supplements here. Available for Android and iOS devices. My GP (not the doctor who treats my osteoporosis) wondered if my early complete hysterectomy (I havent taken estrace in 15 years) and high dosage of thyroid I must take daily, effect the absorption of calcium? Its recommended that calcium and vitamin D supplements be taken Calcium supplements may help support bone and teeth health. Prolia is a monoclonal antibody. Your doctor can also advise you on symptoms of low calcium to look for. * Sex and gender exist on spectrums. Its important to practice good oral hygiene during Prolia treatment. For Prolia, talk to your pediatrician regarding the use of this medicine in children. See what this means for you in the chart below. As with most drugs, Prolia can cause an allergic reaction in some people. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. in your skin, lower stomach area (abdomen), bladder, or ear may happen. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. Common For women with osteoporosis after menopause at high risk for fracture. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. for breast cancer that has not spread to other parts of the body. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It may not cover all possible information. Prolia can also cause low calcium levels. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. We study millions of patients and 5,000 more each day. Fracture in the spine after stopping Prolia treatment. Find out why people need calcium, which foods provide it, and what happens if they consume. It is often used in osteoporosis. A healthcare provider will give you this injection. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. Advertising on our site helps support our mission. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. Prolia is a medicine that may affect the ability of your body to fight infections. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. This medicine may cause jaw bone problems (osteonecrosis). Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). Take good care of your teeth and gums while you receive Prolia. They include bone pain, back pain, and a higher risk of certain infections. (Biosimilars are like generic drugs. Call your doctor for medical advice about side effects. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. This is not a complete list of warnings for Prolia. It is important not to miss your dose. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. for prostate cancer that has not spread to other parts of the body. Sciatica is described as a shooting pain that travels from the lower back down a leg. But certain choices and habits accelerate the process. You can also visit the Prolia manufacturers website to see if they have support options. If you are a healthcare professional, click "I Agree" to continue. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. These medications have different active ingredients and they belong to different groups of drugs. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. Prolia is available as the biosimilar medication denosumab. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Prolia injections administered by a healthcare professional. You may wonder how Prolia compares with the alternative drug Reclast. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium. Serious side effects from Prolia can occur, but they arent common. Learn strategies you can use today. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Stopping Prolia doesnt cause withdrawal symptoms. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. If you drink alcohol, talk with your doctor about how much is safe to drink with your condition. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people Common interactions include nausea among females and fatigue among males. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments Prolia may lower the calcium levels in your blood. Terms of Use. These side effects may be temporary, lasting a few days or weeks. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Q: Does AlgaePlus Increase Bone Mass? Try to avoid being around people who are sick. And some of these side effects are more common with certain uses of Prolia. This lowers your risk for bone fractures. Your side effects from Prolia may also vary depending on your gender. But if you think youre having a medical emergency, call 911 or your local emergency number. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. * For more information about this side effect, see Side effect specifics below. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. If you have low calcium levels, you should not take Prolia. Instead, it belongs to a different group of medications called biologics. Use of the term male in this article refers to sex assigned at birth. Drug class: miscellaneous bone resorption inhibitors. This makes your bones weak and increases your risk for bone fractures or breaks. Dietary calcium is considered safe, but too much calcium in the form of supplements might have some health risks. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. The study uses data from the FDA. If you have a male* sexual partner, they should use birth control during this time as well. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. If you keep this medicine at home, store it in the original carton in a refrigerator. You should also talk with them if you have any serious side effects during Prolia treatment. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. You should always consult your doctor or another healthcare professional before taking any medication. For more information on this side effect, see Side effect specifics below. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. (such as prednisone) for at least six months and are at high risk for fracture. For more information about how these medications compare with each other, ask your doctor. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. You should also talk with your doctor if you have nausea during treatment. Some reports may have incomplete information. If you dont understand something related to your condition or treatment, ask your doctor to explain it to you. Do not use denosumab if you are pregnant. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. All information is observation-only. Do not stop using this medicine without first talking to your doctor. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Learn more details about some of the side effects that Prolia may cause. Although very rare, Prolia can cause serious dental problems and jaw-related side effects. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Last medically reviewed on November 29, 2022. What should I know about Prolia vs. Reclast? Pay special attention to your dental hygiene. But this isnt the case with Prolia. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. What are the possible side effects of Prolia? Any advice? Heres some information on pregnancy, breastfeeding, and Prolia use. Ask your doctor about your own risk. Side effects are possible with Prolia use, but in most cases they go away after a while. Please see Prolia full * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. Also describe any vitamins, herbs, or supplements you use. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Talk with your doctor if youd like to know about taking generic denosumab. You may need to stop using the medicine for a short time. This could include having: Before taking Prolia, share your dental history with your doctor. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. It is often used in osteoporosis. If youre concerned about tingling while using Prolia, talk with your doctor. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. (Hint: it's not just. Youll likely have questions about your condition and treatment choices. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. The Prolia is making my leg bones and jaw bones hurt. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. Prolia is an injection prescribed for certain adults with osteoporosis, which Follow your doctor's instructions. Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. They can treat the infection as needed. Prolia may lower the level of calcium in your blood. (A placebo is a treatment with no active drug.). Its a, Forteos active ingredient is teriparatide. Constipation was also reported as a side effect in females using Prolia for osteoporosis. Throw away a prefilled syringe after one use, even if there is still medicine left inside. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. It is important to check supplement labels to ensure that the product meets United States Pharmacopeia (USP) standards. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more.
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